Doxycycline (Vibramycin, Doxychel)

Class of antibiotic > Tetracycline – inhibits protein synthesis by binding to the 30s subunit of mRNA in bacterial cells. Useful against susceptible gram-negative, gram-positive, protozoal, and rickettsial organisms.

Dose: 100-400mg IV once per day, diluted in 100-400ml of Normal Saline.

Administration: Methods of administration include elastomeric pumps (“homeballs) and gravity bags, although with a 1-4 hour infusion time the elastomerics are a better choice since there is no need to be tethered to an IV pole.